High remission and low relapse with prolonged intensive DMARD therapy in rheumatoid arthritis (PRINT)

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High remission and low relapse with prolonged intensive DMARD therapy in rheumatoid arthritis (PRINT)

OBJECTIVES To determine whether prolonged intensive disease-modifying antirheumatic drug (DMARD) treatment (PRINT) leads to high remission and low relapse rates in patients with severe rheumatoid arthritis (RA). METHODS In this multicenter, randomized and parallel treatment trial, 346 patients with active RA (disease activity score (28 joints) [DAS28] (erythrocyte sedimentation rate [ESR]) > ...

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Combination DMARD therapy for rheumatoid arthritis.

approaches needs to be considered; triple therapy has been reported to be well tolerated at three to five years, while similar data are not available for methotrexate and cyclosporin A. The success of combination DMARD therapy in recent double blind controlled studies is encouraging.2223 As is frequently the case, however, the success of these approaches raises as many questions as it answers. ...

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Prolonged low-dose corticosteroid therapy and osteoporosis in rheumatoid arthritis.

Thirty-one patients with rheumatoid arthritis maintained on prednisolone 5 mg daily for an average period of 9.4 years were assessed radiologically to determine the degree of osteoporosis in their spine and peripheral skeleton. They were compared with a control group of 32 rheumatoid patients who had never received corticosteroids. The steroid-treated patients had more severe osteoporosis than ...

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Combination DMARD therapy including corticosteroids in early rheumatoid arthritis.

A number of reports indicating the growing acceptance of simultaneous therapy with multiple disease-modifying anti-rheumatic drugs (DMARDs), as well as the use of more aggressive treatment measures in the early phases of disease to combat rheumatoid arthritis (RA), have appeared during the last decade. However, only a few randomized controlled clinical trials have been conducted on the use of D...

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Remission in Rheumatoid Arthritis

With advancing therapeutic options, achieving a state of remission has become the treatment goal in rheumatoid arthritis. Agreeing on what constitutes remission and what measures should be used to assess disease activity has remained a challenge. Multiple remission criteria have been devised and modified, all with different strengths and limitations. A consensus definition of remission will nee...

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ژورنال

عنوان ژورنال: Medicine

سال: 2016

ISSN: 0025-7974

DOI: 10.1097/md.0000000000003968